With Twisted Fate receiving a damage buff, the Guardian - Gang composition emerges as exceptionally potent in TFT.
Notably in TFT patch 12.1, champions using Morellonomicon witnessed a surge in skill damage. Riot's attempt to balance Morellonomicon inadvertently fortified several units, with Twisted Fate being a standout example. Skilled players in the Chinese servers successfully experimented with him as the primary carry.

Utilizing Twisted Fate as the main carry involves rerolling to upgrade 1-cost units to 3-stars. With the substantial damage output from both Twisted Fate and Darius, this composition excels in maintaining excellent health during the reroll phase. Consider adding Guardian units like Poppy or Blitzcrank to reinforce Darius's durability.

At level 5, introduce Ziggs to complement the team with additional damage through the Sorcerer synergy. Implement a slow-rolling strategy to expedite Twisted Fate and Darius reaching 3-stars. This strategy also increases the chances of completing 3-star Gang units like Zyra or Shaco. Purchasing available Gang units in the bench is crucial, as reaching the 5-champion threshold unlocks a significant power spike for this composition.

After completing the Twisted Fate and Darius upgrades, prioritize leveling up and incorporating as many Guardian units as possible into the team. Champions like Leona or even Braum are incredibly powerful in the mid-game, making it essential to achieve the 4 Guardian synergy at level 7.
In the final stages of the match, consider bringing in Akali to replace Syndra if you have a 2-star Braum with sufficient durability. If you have the Bang Gang synergy, aim for level 7 to maximize the tribe's potential by giving the emblem to Leona to further enhance her tankiness.

Regarding technology core choices, consider upgrading Perfect Crime early if you have 2-star Darius and Twisted Fate. Additionally, the Backstab Core is an excellent enhancement, making Twisted Fate (usually positioned behind Guardian units) significantly more resilient. As a reroll composition, prioritize cores that provide gold and equipment to facilitate the team-building process.
For itemization choices, Twisted Fate greatly benefits from Blue Buff and Morellonomicon to deal consistent damage in battles. As the third item, consider using any skill damage-boosting items such as Rabadon's Deathcap, Guardian Angel, or Spear of Shojin. If opting for Akali in the late game, Guardian Angel is an indispensable item for her survivability.
