Many viewers seek out new isekai anime in hopes of escaping reality, but not every escape is enjoyable.
Reality check: similar to other genres, isekai anime contains numerous moments that bring tears to fans' eyes, especially when delving into the characters' inner struggles. Although challenging to watch, fans can't deny the profound impact of these scenes. Many isekai anime lead characters to the brink, facing not just one, but a series of intensely sorrowful events.
5. The Moment Rudeus Loses Rationality from His Past Life (Mushoku Tensei: Jobless Reincarnation)
In his previous life, Rudeus was a complete failure, losing all will to live. He provoked some thugs who wanted to punish him for being a nuisance. Eventually, they stripped him naked and tied him to a fence.

Since that day, he stayed indoors, stopped speaking, and grew increasingly despondent. He spent his days gaming non-stop, disregarding his family. Due to these negative experiences, he lived the life of a NEET until a life-saving act for a child in front of a speeding truck.
4. Subaru's Return to Emilia Before Passing Away (Re: Zero)
Subaru leaves Emilia alone, thinking she would be safer. Returning from a fierce battle, he discovers Emilia has no memory of the attacks and depends entirely on him, unable to cope with her own negative emotions.

Subaru returns to Emilia once more, covered in blood, with severe wounds all over and holes in his body. Emilia, even more distressed, cradles him in her arms. Subaru complies, and Emilia gives him a final kiss before he breathes his last.
3. Seiya Fails to Protect the Girl He Likes (Cautious Hero: The Hero Is Overpowered But Overly Cautious)
Seiya's close friend Ristarte journeys with him throughout Cautious Hero: The Hero is Overpowered but Overly Cautious. As they grow closer, they confront the Demon Lord at their final destination, forcing them to defeat him.

In battle, Seiya realizes his weakness against the enemy. Despite his utmost effort, he fails to protect his beloved. The Demon Lord kills her, and she is reborn as a goddess, erasing all memories of Seiya.
2. Rimuru's Struggle to Save Shion and the Villagers in Time (That Time I Got Reincarnated As A Slime)
As Rimuru departs the city, an army assaults the residents. Upon his return, he witnesses numerous innocent villagers slain, but more agonizing is the demise of his beloved guardian, Shion.

Shion valiantly fought to protect the village, and her enemy took advantage of her weakness, ruthlessly killing the loyal guardian. Rimuru stared at Shion's lifeless body for a long time, realizing he had been too lenient with everyone. In a fit of rage, Rimuru massacred thousands of soldiers, becoming a Demon Lord.
1. Subaru Forced to Witness Rem's Torturous Death (Re: Zero)
Even in his worst nightmares, Subaru couldn't imagine a more horrific scene. After forming a close bond with Rem and earning her unwavering trust, he felt compelled to protect her at all costs.

Subaru falls into the clutches of the deranged Petelgeuse Romanee-Conti, and Rem rushes in without hesitation to save him. Unfortunately, she cannot overcome Petelgeuse. After torturing Rem, Petelgeuse hurls her bloodied body towards Subaru. The last words Subaru hears from Rem are words of love.