1. Thanos
Thanos is a supervillain appearing in American comic books published by Marvel Comics. Incredibly powerful and possessing immense strength, Thanos is virtually invulnerable to almost all forms of poison, disease, and physical attack. He also possesses astonishing psychic abilities; he can perceive things across vast distances. Perhaps Thanos's greatest ability is his power of resurrection from death. Thanos's greatest endeavor to conquer the entire universe comes with his pursuit of the Infinity Stones.
Born on the moon Titan of Saturn, Thanos has always been the cosmic enemy of Earth's superheroes, belonging to a powerful branch of genetically altered humans known as the Eternals. Thanos has become notorious for bringing death and destruction from one planet to another. Famous for exterminating entire races to eliminate what he believes is an overpopulated universe. In his quest for his Infinity Stones, he has been turned into stone by the Avengers, Spider-Man, and Adam Warlock, but was resurrected by Death herself.


2. Wenwu
Xu Wenwu is a legendary and almost mythical figure, who rose to power after discovering a set of mythical rings, and founded an army known as the Ten Rings. Wenwu asserts himself as a mighty warlord, who conquered kingdoms over millennia, empowered by the immortality the rings bestow upon him. In modern times, Wenwu continues to seek power, uncovering the ancient city of Ta Lo. Wenwu finally reclaimed his rings when his wife was murdered by the hands of the Gang of Ten. He then trained Shang-Chi to become an assassin to avenge his wife's death.
In the 21st century, Wenwu discovers that Aldrich Killian had been able to recruit Trevor Slattery to impersonate him, adopting the moniker Mandarin, while hijacking the legend of the Ten Rings. Wenwu hears the voice of his late wife, urging him to free her from captivity in Ta Lo. Wenwu sought out his children for assistance, but Shang-Chi and Xu Xialing refuse the request, standing with Ying Nan to thwart their father's army. In an effort to rescue his wife, Wenwu inadvertently releases the Dweller-in-Darkness. Wenwu sacrifices himself to protect Shang-Chi from the Dweller, passing on the Ten Rings to him, before the Dweller drains all of his soul from Wenwu's body and kills him.


3. Erik Killmonger
Erik Killmonger is a supervillain appearing in American comic books published by Marvel Comics. Created by Don McGregor and Rick Buckler, he first appeared in Jungle Action #6. The character is often depicted as a skilled hunter and mercenary born in the fictional African nation of Wakanda, who harbors resentment against the country and its people after his parents were killed when he was young. Raised outside Wakanda, he eventually returns as a revolutionary leader and terrorist to exact his precise revenge, continuously challenging the nation's king and protector, Black Panther, who becomes his foremost adversary.
Killmonger dedicates his life to overthrowing his cousin, T'Challa, to ultimately fulfill his father's plan of seizing control of the world by using all of Wakanda's vibranium, technology to end the oppression of people of African descent worldwide. The character Erik Killmonger has been adapted from the comics into various other forms of media, such as television and video games. Michael B. Jordan portrayed this character in the live-action film Black Panther (2018) of the Marvel Cinematic Universe.


4. Vulture
The Vulture (Adrian Toomes) is a supervillain appearing in American comic books published by Marvel Comics. Toomes is a brilliant yet deranged inventor who designed a special suit that allows him to fly at tremendous speeds. A disgruntled and skilled engineer, Adrian Toomes invented an electromagnetic harness that could provide the wearer with the power of flight and enhance his physical strength. Toomes immediately became obsessed with his newfound power and was determined to make a name for himself under the alias The Vulture.
After turning to a life of crime, The Vulture became an archenemy of the superhero Spider-Man and a founding member of the Sinister Six. Vulture carried out a series of robberies and thefts across New York City when he first crossed paths with Spider-Man. He is the final foe to battle Spider-Man before Doctor Octopus. Since his inception, this character has been adapted into various incarnations, including television shows and video games. In live-action, this character is portrayed by Michael Keaton in the Marvel Cinematic Universe film Spider-Man: Homecoming (2017) and Sony's Spider-Man Universe film Morbius (2022).


5. Loki
Loki, known as the Trickster God, is a fictional character in the Marvel Cinematic Universe (MCU), based on the Marvel Comics character and the Norse mythology deity of the same name. Loki made his debut in the 2011 film Thor and has since become a recurring and significant character in the Marvel Cinematic Universe; following Loki's initial demise in Avengers: Infinity War in 2018, a variant of him from an alternate timeline was introduced in Avengers: Endgame, diverging from the events of The Avengers (2012).
The character of Loki has been constructed with borrowed elements from various historical traits and storylines of the character in Marvel Comics. Like in the comics, Loki generally serves as an antagonist in the Marvel Cinematic Universe, constantly seeking to conquer Asgard or Earth, aligning himself with more powerful villainous characters to achieve his nefarious purposes. Loki has a particularly antagonistic relationship with his foster brother Thor, known for being both an ally and later a betrayer to Thor and others, often returning from apparent deaths. Throughout character development across the film series, Loki has had opportunities to become both less of a supervillain and more of an antihero.


6. The Grandmaster: Architect of Games
The Grandmaster is a fictional character appearing in American comic books published by Marvel Comics. The character first appeared in The Avengers #69. Trapped on the planet, En Dwi Gast transformed himself into the grandiose Grandmaster, establishing a dictatorial regime over its citizens and driving them into madness with a series of battles among some of his mightiest slaves known as the Contest of Champions. When the Grandmaster chose Thor as his new contender, he was soon horrified to learn that Thor knew Hulk.
As The Grandmaster feared, Thor quickly escaped Sakaar along with Hulk, leading to a new uprising that saw him lose his grandeur before the people of Sakaar. The Grandmaster is one of the oldest living beings in the universe, originating from one of the first intelligent species to evolve after the Big Bang. He is one of the oldest Elders in the Universe and has mastered most of the games and whims of various civilizations. Various sources describe him as the brother of the Collector. While En Dwi Gast's brother Taneleer Tivan is obsessed with collecting various artifacts, En Dwi Gast is obsessed with controlling life forms to fight to the death.


7. Helmut Zemo: Ingenious Adversary
Helmut Zemo, known as a fictional character appearing in Marvel Comics, often serving as the disloyal adversary of the superhero Captain America and the Avengers. He is the son of Baron Heinrich Zemo and the thirteenth Baron Zemo in his family lineage. Helmut started as an engineer until he became enraged upon reading a report of Captain America's return and his father's death. Helmut first appeared in the Marvel Cinematic Universe under the alias Phoenix, seeking revenge on Captain America for his father's death.
In a battle with Captain America, Adhesive X permanently glued Heinrich's hood to Helmut Zemo's face, unable to remove it. Helmut Zemo allied with Primus I and the half-rat/half-human mutant Vermin, kidnapping Captain America's childhood friend, Arnold Roth, to lure Captain America into a trap. He forced Captain to fight the mutants before revealing that he knew Captain America's secret identity. The character first appeared in Captain America #168 and was created by Roy Thomas, Tony Isabella, and Sal Buscema. In 2009, Helmut Zemo was ranked as the 40th greatest comic book villain of all time by Imagine Games Network.


8. Hela: Goddess of Death
Hela is a fictional character appearing in American comic books published by Marvel Comics. Hela Odinsdottir is the ruthless goddess of death of Asgard and the former ruler of Hel. Held captive by her father Odin for millennia, Hela was released from her prison after his death and sought to reclaim her power over Asgard while engaging in a series of confrontations with her two brothers, Thor and Loki. Upon gaining power from Asgard, Hela plotted to rule over Asgard and establish an empire for herself.
Hela sought to expand her power to those who had died living in Valhalla. These efforts often brought her into conflict with Odin or his son Thor. She once clashed with Thor when he was on the brink of death after battling the Destroyer. She later stole a portion of Odin's soul while he was in the Odinsleep as part of Loki's plan to seize Asgard, thus creating a powerful entity known as the Infinity. Hela then unleashed the Infinity upon the universe. The Infinity became so powerful that it usurped Odin's control. Hela killed Thor after hunting him down by placing him in peril, but restored his life after a plea from Sif.


9. Mysterio: Illusionist Extraordinaire
Mysterio is a primary antagonist in Marvel Comics, often a foe of Spider-Man, Deadpool, and Daredevil. He is a supervillain primarily using illusions and other gadgets to commit crimes. The identity of Mysterio has been adopted by various individuals over the years, but most notably used by Quentin Beck, a former actor and special effects artist who would become one of Spider-Man's archenemies. Mysterio early on battled Spider-Man, ultimately defeating and humiliating him using his array of tricks and special effects.
Mysterio was hailed as a hero before Spider-Man fought him again and exposed his true intentions. Since then, Beck became a member of one of Spidey's main Rogue's Galleries, frequently clashing with the web-slinger solo, and also joining Doctor Octopus's supervillain team, the Sinister Six. He once assumed the identity of a psychiatrist and nearly convinced Spider-Man that he had lost his mind, revealing his secret identity in the process.


10. Winter Soldier: Bucky's Transformation
Bucky Barnes is a former soldier and the closest friend of Steve Rogers, Captain America, since childhood. Upon being found, Barnes was then brainwashed and equipped with a new controller to later become their special operative, known as Winter Soldier. Over the next fifty years, he had the task of eliminating anyone posing any kind of threat to HYDRA, including Howard Stark and his wife, Maria. Amidst all these assassination missions, Winter Soldier would be brought back to a cryogenic area to ensure his longevity. In 2014, Winter Soldier was ordered by Alexander Pierce to kill Nick Fury, to ensure that all of Pierce's plots with Project Insight could proceed.
Following the Battle at the Triskelion, Winter Soldier is now no longer brainwashed, left to wander to recall his violent past. Two years later, Barnes is accused of the Vienna International Centre bombing, robbing T'Challa of his life, among many other innocent lives. As Black Panther then seeks revenge for his father's death, Barnes is repeatedly rescued by Captain America, sparking the Avengers Civil War as a team of Avengers led by Iron Man is dispatched to apprehend him. Surviving Stark's vengeance, Barnes is pardoned in Wakanda by T'Challa and placed in cryostasis until all HYDRA control can be purged.


11. Ultron: The Age of Artificial Intelligence
Ultron: The Digital Nemesis is an artificial intelligence originally designed to be part of a peacekeeping program created by both Tony Stark and Bruce Banner, using code decrypted from Loki's Mind Stone. However, when the Mind Stone activated him, Ultron's original programming directive, aimed at protecting Earth from all threats domestic and extraterrestrial, quickly became corrupted by the stone. Accessing the internet and reviewing human history, Ultron sees humanity as the greatest threat to peace on Earth and seeks to carry out extinction-level genocide, intending for him and his Ultron Sentries to be the only ones left operating on Earth, also viewing the Avengers as the greatest threat and carrying out his mission to end them.
With the assistance of Pietro and Wanda Maximoff, Ultron begins to enact his mission to create a weapon capable of eradicating all organic life on Earth, using resources stolen from Baron Strucker and Ulysses Klaue to do so. Despite being challenged by the Avengers, Ultron briefly prevails, albeit losing the support of Maximoff. Ultron then creates the Doomsday Trigger comprised of Vibranium and Chitauri technology, designed to raise Novi Grad from Earth, intending to use it as a meteor to wipe out all of humanity. Ultimately Ultron's plan is thwarted by the Avengers.


12. Ego
Ego, known as a Celestial, a primordial and powerful being, is also the biological father of Peter Quill. Seeking meaning in his existence, Ego devised a plan to remake the entire universe through a genocidal event called the Expansion, using 'seeds' planted on worlds to turn them into extensions of himself, thus eradicating all other life in the universe. However, this process required two Celestials, so Ego traversed the universe, seeking out humanoid alien children everywhere in an attempt to create a Celestial heir. Ego hired the Yondu Ravager Clan to abduct and transport some of these children to his planet.
Upon hearing a tale of a man from Earth who wielded the Infinity Stone without perishing, Ego realized this man must be the son he had sired with Meredith Quill. Ego and Quill first reunite on Berhert after saving the Guardians from hundreds of Sovereign drones. As Quill inadvertently inherits Celestial genes, Ego bonds with his biological son, where he ultimately reveals his desire to remake the universe by entrancing Quill into compliance.

