Many nerfs to reroll comps have paved the way for compositions relying on 4-cost champions to take the spotlight in TFT Patch 12.5b.
Renata - Duelists
Once a formidable force in the 6.5 meta, the Renata - Duelists comp faced direct nerfs and nearly vanished from the meta in the past two weeks. However, with the release of TFT Patch 12.5b, there's a high likelihood that this comp will make a strong comeback as its 'adversaries' have been significantly weakened. Additionally, the substantial healing buff to Rek'Sai contributes to the comp's resilience in the mid-game.

Fundamentally, Renata - Duelists is a gold hoarding composition, reaching level 8 and rerolling continuously to upgrade crucial 4-cost units to 2-star. This makes the comp a challenging match for team-comps with early reroll capabilities, preventing them from reaching their power spikes at level 8. With the notable nerfs to various units that can be rerolled into carry roles, such as Twitch, Talon, Ashe, the gold hoarding strategy of the Renata - Duelists team has a chance to shine.
The Inventor
Reigning as the 'King of all team-comps,' The Inventor still proves to be a highly efficient climbing comp despite direct nerfs in Patch 12.5b. With reroll strategies taking a heavy hit in Patch 12.5b due to substantial power reductions for low-cost carries, The Inventor finds an opportune moment to dominate the meta. Maintaining superior health even with 2-star 1-2 cost units makes it an excellent choice in the current environment.

Moreover, the 'economy' meta at level 8 aligns well with The Inventor, allowing for versatile choices like Jhin, Irelia, Kha'Zix for item stacking. With attack stats buff from Tech Bear and strong protection from Seraphine, Zilean, physical damage carries thrive comfortably in The Inventor comp. Even with many magic items, you can opt for a traditional playstyle relying on Seraphine.
Ahri - Frost Gang
Despite a damage nerf, Ahri is arguably the most indirectly buffed champion in Patch 12.5b. Her gameplay revolves around lasting longer in battles for continuous ultimates and creating a snowball effect. However, in the early 12.5 meta dominated by reroll strategies, Ahri struggles to survive long enough to unleash 2-3 ultimates. Thus, with numerous nerfs to reroll comps, Ahri emerges as the most benefited champion.

To build a successful Ahri - Frost Gang team, it's crucial to upgrade both Ahri and Braum to 2 stars. In some special cases, players even use two 2-star Ahris and Braums when acquiring a Perfect Team Pair core. These are expensive 4-cost champions, making the Ahri - Frost Gang team more suitable for a gold hoarding and 'economy' meta, typically 'rolling down' at level 8, as in the upcoming 12.5b patch.