The most powerful technique of Otsutsuki Kaguya is the devastating wide-area damage technique in Naruto.
In the 700 chapters of the Naruto manga, Masashi Kishimoto introduced numerous ninja techniques with various features and levels of power. Many of these techniques have immense destructive capabilities. This raises the question among fans: which jutsu is the most dangerous, causing the most devastating damage in the entire history of the ninja world?
Firstly, it's important to note that we will only consider techniques whose main objective is to obliterate everything around. Therefore, techniques like the Infinite Tsukuyomi illusion will not be counted. This is because the primary function of the Infinite Tsukuyomi is to initiate an illusion that can plunge the entire world into an eternal dream.
Thus, based on what has been demonstrated and presented in Naruto, the jutsu with the widest-ranging destructive power, causing the greatest damage, is The Expansive Truth-Seeking Ball. This is the ultimate ability Kaguya uses in the battle against Team 7 in the Fourth Great Ninja War.

There are 3 ways to obtain the Truth-Seeking Balls in Naruto. The two most common methods are using the chakra of the Six Paths Sage or becoming a Jinchuriki of the Ten-Tails. The remaining method is to use the power of the Tenseigan dojutsu. These are black, hand-sized orbs that users can manipulate and change the shape of to serve various purposes.
The Truth-Seeking Balls harness the essence of Yin and Yang, hence possessing tremendously devastating power. These orbs are so potent that they can reduce opponents to nothingness in an instant. According to Hiruzen Sarutobi, they operate somewhat similarly to the Uzumaki clan's selective bloodline techniques.

Kaguya pushed the limits of the Truth-Seeking Balls by using her own chakra and the victims in the Infinite Tsukuyomi, forming the Expansive Truth-Seeking Ball to have enough power to create a new dimension.
According to the Fourth Naruto Databook, the Expansive Truth-Seeking Ball is powerful enough to erase the entirety of space-time, demonstrating just how dangerous this jutsu truly is.