Effexor and Effexor XR are the brand names for venlafaxine in the United States, a medication prescribed for millions to treat depression, anxiety disorders, and panic attacks. Effexor is a prescription drug, so it is important to follow your doctor's instructions, including determining the right time to stop taking it. You can stop using Effexor by gradually reducing the dosage to minimize withdrawal symptoms.
Steps
Reduce the medication dosage

Consult with your doctor. Regardless of your plan, it's essential to get advice from your doctor before discontinuing Effexor. Even if you feel better or must stop due to pregnancy or other reasons, abrupt cessation can have serious consequences. Your doctor can help you decide on alternative treatments or the complete discontinuation of Effexor.
- Avoid stopping or reducing your Effexor dosage without consulting your doctor. Always follow your doctor's prescribed guidance.
- Discuss your reasons for wanting to stop the medication with your doctor. Be honest so your doctor can explore the best treatment options for you. There are various reasons you might wish to stop Effexor, such as feeling better, pregnancy, breastfeeding, or drug interactions.
- Follow your doctor's advice. If you have any questions, ask your doctor about the benefits and risks of stopping the medication and about other possible therapies they may recommend. There is always a secondary treatment plan available if necessary.

Don't rush. No matter how long you've been taking Effexor, you should allow plenty of time for the process of discontinuation. Even if you attempt to quit abruptly, you may experience withdrawal symptoms that could worsen your condition. Depending on your dosage, it might take anywhere from a week to several months to stop Effexor. Based on your current health and dosage, your doctor can help determine how long it will take for you to safely stop taking Effexor.

Plan your dosage reduction. You will need to gradually reduce your Effexor dosage. The best approach is to work closely with your doctor to create a personalized tapering plan tailored to your condition. This will involve determining how much to reduce the dosage and how frequently, depending on your response to the medication and any withdrawal symptoms. Consult your doctor to ensure your plan is feasible.
- Spend 1-2 weeks reducing the Effexor dose if you’ve been taking it for less than 8 weeks. If you’ve been on Effexor for 6-8 months, wait at least 1 week between dosage reductions. For patients on a maintenance dose of Effexor, the tapering process will be slower. For instance, you should not reduce more than ¼ of the dose every 4-6 weeks.
- Write your tapering plan down on paper or in a notebook, along with notes on your mood or any issues you encounter. For example, your plan might look like: “Initial dose 300 mg; first reduction: 225 mg; second reduction: 150 mg; third reduction: 75 mg; fourth reduction: 37.5 mg.”

Split the pills. Once you’ve discussed your plan with your doctor, make sure your dosage aligns with that plan. You can ask your doctor for a prescription for specially dosed tablets, ask a pharmacist to split your medication, or use a pill cutter to do it yourself.
- If you’re taking Effexor XR, you’ll need to switch to regular Effexor. Effexor XR is an extended-release formula, and cutting the pills will affect how the medication is released. This could lead to the risk of taking an overdose, as the drug would be released too quickly.
- Purchase a pill cutter from a pharmacy or a medical supply store. Ask your pharmacist or sales associate if the product is suitable for your needs.

Monitor your symptoms. As you reduce your Effexor dose, it’s important to keep track of your mood and physical symptoms. You may even want to check your mood weekly. This will help identify any potential issues or alert you if you need to taper the medication more slowly.
- Keep a weekly journal as part of your tapering plan. Record your dose and how you’re feeling. If you’re feeling comfortable and experiencing fewer withdrawal symptoms, you can continue tapering according to schedule. Just remember not to rush the process to prevent withdrawal symptoms.
- Consider keeping a “mood calendar” for each day of the week. You can rate your mood from 1-10 daily to identify any patterns or issues that arise as you taper off the medication.

Stop reducing the dose if necessary. If your symptoms worsen or if you experience severe withdrawal symptoms, consider halting the dose reduction. You can always add half a dose back or return to the original dose until your condition improves. Once you’re feeling better, you can resume tapering at a slower pace.

Stay in contact with your doctor. Throughout the process of tapering off Effexor, it’s important to keep your doctor informed about your progress. Let them know if you encounter any obstacles or experience withdrawal symptoms. Your doctor may suggest a new plan or an alternative treatment to help manage any issues or withdrawal symptoms during the discontinuation of Effexor.
- If you struggle with stopping Effexor, your doctor might prescribe fluoxetine (Prozac) as an alternative. This will allow you to taper off the fluoxetine without experiencing withdrawal symptoms.
Managing withdrawal symptoms

Recognize withdrawal symptoms. Venlafaxine is among the drugs most likely to cause withdrawal symptoms when discontinued. As you reduce your Effexor dosage, you may or may not experience withdrawal symptoms, but it’s best to be aware of the typical ones. Ask your doctor about ways to alleviate any of the following symptoms:
- Restlessness
- Dizziness
- Fatigue
- Headaches
- Vivid dreams
- Insomnia
- Nausea
- Irritability
- Anxiety
- Chills
- Night sweats
- Runny nose
- Tremors
- A sense of unease or fear
- Muscle aches
- Gastrointestinal issues
- Flu-like symptoms
- Depression
- Suicidal thoughts

Seek emergency help. If you experience persistent depression or suicidal thoughts while discontinuing Effexor, contact your doctor or go to the nearest hospital as soon as possible. Your doctor will help manage your symptoms and may intervene to prevent self-harm.

Find support. During the process of stopping Effexor, you will need as much support as possible. This will help you cope with withdrawal symptoms and potential side effects.
- Continue to inform your doctor about your progress. You might even need to see a psychiatrist or a psychologist for alternative therapy during the withdrawal process. This can help reduce symptoms and possibly provide new coping mechanisms.
- Let your family and friends know that you are discontinuing Effexor and might experience withdrawal symptoms. Share with them ways they can assist you during this time.
- Consider taking time off work if necessary. Be honest with your manager about your situation. If you can’t take time off, ask about possible adjustments you can make to contribute to the company while experiencing withdrawal symptoms or a relapse.

Engage in physical activity. Exercise helps produce serotonin and can be highly effective in combating depression. If you're discontinuing Effexor, regular physical activity can compensate for the absence of the medication. This also aids in managing withdrawal symptoms and can help improve your overall comfort.
- Try to aim for 150 minutes per week, or five 30-minute sessions of moderate-intensity activity. Activities like walking, jogging, swimming, or cycling will boost your mood. Consider incorporating yoga or Pilates, which not only increase your weekly exercise time but also enhance mood and promote relaxation.

Eat nutritious foods. A healthy diet can enhance the effects of exercise and rest. Balanced meals based on the five food groups help maintain stable blood sugar levels and prevent nausea or stomach issues.
- Choose foods from all five food groups. Include plenty of fruits, vegetables, grains, protein, and dairy. Aim to make vegetables half of your plate at each meal.
- Consider adding magnesium-rich foods like almonds, avocados, spinach, soybeans, black beans, salmon, halibut, oysters, peanuts, quinoa, and brown rice to your diet.

Manage stress. It’s important to minimize stress if you’re under pressure. Stress can exacerbate withdrawal symptoms and even trigger anxiety.
- Avoid stressful situations whenever possible. If you can’t, take a moment to step away, breathe deeply, or ask for a break like ‘going to the restroom’ or ‘taking a phone call.’ A brief pause can help alleviate stress.
- Allow yourself to indulge in regular massages to help you relax.

Rest as much as possible. Discontinuing Effexor may result in multiple withdrawal symptoms, and getting sufficient rest is key to maintaining a good mood and reducing stress. This includes establishing a regular sleep schedule and taking naps when needed to help you feel more refreshed.
- Go to bed and wake up at the same time every day. Aim for at least 7 hours of sleep each night, even on weekends, to minimize symptoms.
- Take short naps (20-30 minutes) as needed. You’ll feel more alert and reduce withdrawal symptoms.
Warning
- Avoid stopping Effexor on your own. Always consult with your doctor before making any changes to your medication regimen. Do not take any other medications while on Effexor without first discussing it with your healthcare provider.
- Continue taking Effexor even if you're feeling better. Stopping the medication prematurely may cause your condition to worsen.
