CAUTION: This article includes graphic surgical images. It focuses solely on current surgical practices, excluding outdated or obsolete methods, as well as cosmetic surgeries.
1. Hemispherectomy

Surprisingly, this surgical technique entails the removal or deactivation of one entire brain hemisphere. It is primarily employed to address severe seizure disorders where epilepsy originates in a widespread area of one brain hemisphere and cannot be controlled with medication. First performed on a human in 1923 by Walter Dandy, this procedure results in partial or complete paralysis on the side of the body opposite the removed hemisphere. Over time, neurons from the remaining hemisphere often compensate by forming new connections to assume the functions of the lost hemisphere.
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Referred to as translumbar amputation, this procedure involves the removal of the body's lower half above the pelvis. This results in the elimination of the sexual organs, anus, rectum, legs, pelvic bones, and urinary system. It is an extreme and disfiguring operation, reserved for life-threatening conditions such as osteomyelitis, tumors, severe trauma, or persistent pelvic ulcers. Performed in only a handful of cases, the surgery is typically conducted in two phases, though a single-stage approach is possible. The first phase involves diverting waste functions through a colostomy (rectum) and ileal conduit (bladder), followed by the amputation itself.
3. Bilateral Cingulotomy
This surgical procedure targets the brain to manage extreme cancer-related pain. It works by disabling the cingulate gyrus, a small brain region linking the limbic system to the frontal lobes. While its application in psychosurgery (treating mental disorders) remains highly controversial, it has largely replaced lobotomy. Its effectiveness in alleviating cancer pain is well-documented, but its use for treating depression lacks substantial evidence.
4. Endoscopic Thoracic Sympathectomy
ETS involves dissecting parts of the sympathetic nerve trunk to address severe hyperhidrosis (excessive sweating). A peculiar side effect of this surgery is the loss of the ability to blush, making it a cosmetic option for those who blush excessively. If performed on only one side, the patient would blush on the untreated side while the treated side remains unaffected. Consequently, the procedure is always conducted bilaterally.
5. Vaginectomy
A Vaginectomy involves the partial or complete surgical removal of the vagina, typically as a treatment for certain cancers or as part of gender-affirming surgeries. Surgeons often reconstruct the vagina post-surgery using tissue from other areas of the patient's body.
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Lobotomy is a highly debated medical procedure involving the destruction of the brain's frontal lobes. This is achieved by severing or damaging the connections to and from the prefrontal cortex. Although rarely performed today, it was historically used to treat various mental illnesses, such as schizophrenia. The procedure often leads to significant personality alterations or even cognitive impairments. Notably, President Kennedy’s sister underwent this surgery.
7. PenectomyRosemary Kennedy, sister of President John F. Kennedy, underwent a lobotomy after her father expressed concerns about her mood swings and increasing interest in men. Walter Freeman personally conducted the procedure. Unfortunately, instead of achieving the intended outcome, the lobotomy left Rosemary with an infantile mental state, causing incontinence and long periods of blankly staring at walls. Her ability to speak deteriorated to incoherent babbling. To prevent political fallout, her father concealed the true nature of her condition for years, attributing it to mental retardation. In her honor, her sister Eunice Kennedy Shriver established the Special Olympics in 1968.

A Penectomy involves the complete or partial removal of the penis, typically as a treatment for cancer or due to complications from circumcision. While some men opt for this procedure voluntarily as a form of body modification, medical professionals debate whether the desire for penile amputation stems from a psychological condition, potentially classifying it as part of body dysmorphic disorder.
8. Circumcision
Circumcision, a widely practiced procedure, is often performed for religious reasons (e.g., among Jews and Muslims) or for claimed health benefits. However, it remains controversial as it involves the surgical removal of the foreskin, usually performed on infants without their consent. Some men experience psychological distress as a result, leading to the next unusual surgery: foreskin restoration.
9. Foreskin Restoration
Foreskin restoration involves techniques, both surgical and non-surgical, to stretch the remaining penile skin, creating the appearance of a natural foreskin covering the glans. This procedure is often pursued by circumcised men, those with injuries, or individuals seeking a longer foreskin, including men with phimosis. Motivations include regaining control over their sexual organs and restoring self-esteem. Historically, during World War II, European Jews and men circumcised for medical reasons sought clandestine foreskin restoration to evade Nazi persecution.
10. Lindbergh Operation
The Lindbergh Operation holds a special place in medical history as the first fully robotic surgery guided remotely by doctors via telecommunications. Conducted on September 7, 2001, by Professor Jacques Marescaux and his IRCAD team, the procedure involved removing a patient's gallbladder in Strasbourg, France, while surgeons controlled the ZEUS™ Robotic Surgical System from New York. This groundbreaking operation demonstrated the feasibility of overcoming transmission delays in long-distance surgeries, enabled by a high-speed fiberoptic network provided by France Telecom.
Sources: Wikipedia
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