Buzz
As the CDC worked on recommending the updated bivalent COVID booster vaccines (by the way, most of us should schedule our appointments), they also highlighted the importance of Evusheld, a treatment that can offer additional protection for immunocompromised individuals aged 12 and older.
Immunocompromised individuals have immune systems that might not function optimally. A weakened immune system can stem from certain medical conditions or from medications that suppress immunity, such as treatments for cancer or following an organ transplant.
For some immunocompromised individuals, receiving the COVID vaccine may not be advisable at all. For many others, the vaccine is safe but doesn’t offer the same level of protection as it does for those with strong immune systems. (This is why immunocompromised individuals are recommended to receive three doses instead of two when getting the Pfizer or Moderna COVID vaccines initially.)
If you were unable to receive the COVID vaccine, or if you belong to a group that may not be as well protected, Evusheld can provide an additional layer of defense.
What exactly is Evusheld?
Evusheld is classified as “pre-exposure prophylaxis” for COVID, available for individuals who are moderately to severely immunocompromised. The CDC provides guidelines on Evusheld here. It is administered every 6 months.
The treatment involves two injections of monoclonal antibodies, tixagevimab and cilgavimab. Essentially, instead of stimulating your body to produce its own antibodies, you're being provided with pre-made antibodies. You should still also receive your COVID vaccine, if you’re eligible.
Who is eligible for Evusheld?
Evusheld is intended for individuals who are moderately or severely immunocompromised or those who are unable to receive full vaccination with a standard COVID vaccine (such as having an allergic reaction to the first dose or knowing you are allergic to a vaccine ingredient). You must be at least 12 years old and weigh no less than 88 pounds.
This treatment cannot be administered immediately after receiving a COVID vaccine (you must wait two weeks after your final dose), and it’s not suitable if you’re currently sick with COVID or in quarantine due to a recent exposure.
According to the FDA, conditions that may cause someone to be moderately or severely immunocompromised include:
Receiving cancer treatment.
Taking immunosuppressive medications following an organ transplant.
Undergoing CAR-T-cell therapy or hematopoietic stem cell transplants.
Moderate to severe medical conditions resulting in immunodeficiency.
Advanced or untreated HIV infection.
Receiving high-dose corticosteroids or other immune-altering medications or biologics, such as chemotherapy, TNF blockers, and B-cell depleting agents.
How can I obtain Evusheld?
Evusheld can only be obtained with a prescription. The government has acquired doses of Evusheld to provide to eligible individuals, so you should be able to receive it at no cost or at a very low price, according to the Department of Health and Human Services.
You can use this locator map to find a clinic offering Evusheld. Be sure to call ahead, as walk-ins may not be accepted. Calling first allows you to confirm they have the treatment available and gives them time to process your prescription.
