With the start of the New Year, many people are already considering their resolutions, and weight loss is one of the most popular goals. Here are some well-known diet pills that claim to offer rapid, easy, and guaranteed weight loss results. If you prefer a natural approach to shedding pounds, take a look at the Top 10 Natural Weightloss Aids.
10. Hoodia

Hoodia Gordonii is promoted as a natural appetite suppressant, allegedly reducing hunger cravings. In theory, with enough Hoodia in your system, you could go for days without feeling hungry. However, there is no conclusive scientific research proving that Hoodia effectively suppresses appetite in humans. Consequently, the safety and efficacy of Hoodia Gordonii as a dietary supplement remains unsupported.
9. Hydroxycut
Hydroxycut is often advertised as a metabolism enhancer and appetite suppressant. Originally, Hydroxycut gained widespread attention because of the inclusion of ephedra. However, after ephedra was banned in the United States, Hydroxycut's popularity significantly declined. Despite claiming to be 'clinically proven' as a 'fat burner,' there are no clinical studies available to back up these claims.
8. TrimSpa
TrimSpa is advertised as a product that helps suppress appetite. Originally, it included ephedra, which was later banned in the U.S. The new TrimSpa formula X32 no longer contains ephedra and instead features Hoodia gordonii as its active ingredient, along with stimulants like caffeine and theobromine. Notably, TrimSpa's spokesperson, Anna Nicole Smith, passed away, sparking much controversy about the cause of her death.
7. CortiSlim / Relacore
Cortislim and Relacore are not marketed specifically as weight loss products. Their primary function is to lower cortisol, often called the 'stress hormone.' The idea behind these supplements is that stress contributes to 'belly fat,' and by reducing stress, fat can be reduced. These pills claim to lower cortisol levels as a means of achieving stress reduction.
6. Stacker 2
Stacker 2 stands out on this list as it is specifically marketed as a metabolism booster. The original formula of Stacker 2 was based on a well-known combination used by many athletes and bodybuilders: Aspirin (white willow bark), ephedrine (ma huang), and caffeine. Together, these ingredients trigger thermogenesis, which accelerates metabolism and increases the rate at which calories are burned. After the ban of ephedra, Stacker 2 has replaced it with other stimulant ingredients.
5. Propolene
Propolene is arguably the most credible product on the list. Its main active ingredient is glucomannan, a water-soluble polysaccharide that makes up 40% of the dry weight of the roots or corm of the konjac plant. In simple terms, glucomannan absorbs water and forms a gel-like mass, which helps to create a feeling of fullness without eating. In obese patients, taking 1 gram of glucomannan with 8 ounces of water 1 hour before each of three meals daily over 8 weeks resulted in an average weight loss of 5.5 pounds. This product is also supported by a clinical study available on a government website.
4. Alli / Xenical / Orlistat
Alli originally began as the prescription drug Xenical. It is marketed as a fat-burning product, though its main action is not directly burning fat. Instead, it works by preventing the absorption of dietary fats, which reduces overall caloric intake. Additionally, it is recommended to follow a reduced-calorie, low-fat diet while using the product. A significant downside to this pill is the 'treatment effects' – if the diet isn’t adhered to, excess fat will be expelled uncontrollably. It’s advised to wear dark clothing when starting and avoid public places for the first few days. It's also important to note that Alli is the only weight loss product approved by the FDA, although the FDA regulates all dietary supplements.
3. Leptoprin / Leptopril / Formula 9
Leptoprin is targeted specifically at individuals who are 'significantly overweight.' Leptopril is essentially the same formula, marketed as a generic version by the same company. While it shares similarities with many diet pills, Leptoprin is most notorious for its steep price of $153 per month. Originally marketed as Anorex, the product's formula was based on the ECA Stack (refer to number 6 on this list), containing nearly identical ingredients. Following the ephedra ban, the product was renamed Leptoprin and its formula was modified, although it still retained many components of Stacker 2. In 2007, the formula was changed again after the parent company, 'A.G. Waterhouse' and 'Generix Labs,' discontinued a failing product named 'Formula 9.' The current Leptoprin/Leptopril formula is identical to Formula 9. As an interesting tidbit, after the formula change, some Leptoprin/Leptopril capsules were actually stamped with 'Formula 9.'
2. Zantrex-3
Zantrex-3 is marketed to people under 30 as an energy-boosting, fat-burning diet pill. The formula contains three different types of caffeine, amounting to a total of approximately 300 mg per serving, which is roughly equivalent to 3-4 cups of coffee. This high caffeine content is responsible for most of the side effects associated with Zantrex. Despite its claims, its effectiveness as a diet pill is debatable, as the company asserts that Zantrex-3 is specifically designed for individuals aiming to lose only 5-10 pounds. A fun fact: Dustin Diamond claimed to have used Zantrex-3 and lost 13 pounds in two weeks while participating in the VH1 show 'Celebrity Fit Club.'
1. Estrin-D / Akavar 20/50
Estrin-D is marketed as the first diet pill specifically designed for premenopausal and menopausal women. Akavar 20/50 is promoted as 'the fastest, easiest weight loss ever' and claims that you can 'eat all you want and still lose weight.' You might wonder why these two products are listed together. Here's why: they are exactly the same product. Both contain the same ingredients, with one exception. When Akavar was initially released in March 2007, it contained DHEA, the ingredient that differs from Estrin-D. However, due to a highly successful marketing campaign, Akavar quickly sold out of its DHEA-containing formula. By May 2007, Akavar was being produced without DHEA, making it technically different from Estrin-D. The product claims to work by promoting 'automatic calorie restriction,' meaning you feel full faster. The company also claims that preliminary studies suggest it affects ghrelin, the 'hunger hormone.'
Honorable Mention: These products didn’t make the list because they are not in pill form: L. A. Weight Loss, Nutrisystem, Enviga Tea.
Afterword: Neither the contributor nor the List Universe endorses any of these products. If you decide to try any of them, it is recommended that you check the guarantee and consult with a medical professional. In the realm of miracle pills, be cautious and don’t take anything at face value. It’s also worth mentioning that the same company behind Relacore manufactures Leptoprin/Leptopril/Formula 9, Zantrex-3, and Estrin-D/Akavar 20/50.
Notable Omission: Phentermine / Duromine
Contributor: Mystern
