Buzz
For years, I was aware that NSAIDs such as ibuprofen are meant to relieve menstrual cramps, but they never seemed effective for me. I later realized I was using them incorrectly—they are most effective when taken before the cramps intensify.
“We advise individuals to begin taking ibuprofen or naproxen a day before they expect their period,” explains Heather Giambo, a pediatric emergency doctor based in New York City. (While not everyone has a predictable cycle, those who do can benefit from this strategy.)
Both ibuprofen (Advil, Motrin) and naproxen sodium (Aleve) are effective because they inhibit the production of prostaglandins. Prostaglandins signal the uterus to contract, which is necessary for expelling menstrual blood—but intense contractions can cause pain, leading to cramps.
The key is to control prostaglandin production before it escalates. This means taking painkillers early maximizes their effectiveness. Delaying reduces their impact until the next cycle: “Once prostaglandins are present, they’re already active,” explains Giambo. My old approach of waiting to gauge the severity of cramps before deciding to take Motrin was far from ideal.
Giambo also highlights that individuals with specific health conditions, such as a history of stomach bleeding, should avoid these medications. If you’ve never used them before, consult your doctor first.
