If you want to reduce the size and redness of an unexpectedly large pimple, you can crush Aspirin and mix it with water to apply directly. However, caution is needed with this method, as the long-term effects of Aspirin use are not well understood. One thing is certain: Aspirin thins the blood, and applying too much on the face (which allows the skin to absorb it into the bloodstream) can be harmful.
Steps
Applying Aspirin on the Face

Crush 1 Aspirin tablet completely into powder. You can use 1-3 tablets, but no more. Just as it is unsafe to take too many Aspirin orally, it is also important not to overuse it on the face without consulting a doctor. Using more than 2 tablets, especially in a short period (5-10 tablets daily), can thin the blood as Aspirin is absorbed into the bloodstream. While it does not cause ulcers, excessive Aspirin absorption is not recommended.

Mix the Aspirin powder with water. Use about 2-3 parts water for every 1 part of Aspirin. The mixture should be thick and slightly gritty, meaning do not use more than a few drops of water (since you're only using one Aspirin tablet).

Apply the mixture directly onto the pimples. Make sure to use a clean cotton swab or wash your hands thoroughly with soap and/or Isopropyl alcohol before applying with your fingers, to ensure you are not adding bacteria to your skin.

Leave the Aspirin on the pimples for about 15 minutes. Do not leave it on for longer, as the skin will absorb too much Aspirin into the bloodstream, which will remain in the body for a period of time.

Use a clean, damp cloth to wipe away the Aspirin. This step can also be used as a gentle exfoliation.
Try using more natural ingredients to reduce pimples.

Use Tea Tree Oil. Tea tree oil may be more effective than benzoyl peroxide in reducing wounds and treating acne. Apply a small amount of tea tree oil directly to the pimple until it disappears.

Apply raw potato slices to the skin. Raw potato can serve as an anti-inflammatory when applied to the skin. Leave it for a few minutes, then rinse off any potato residue with cold water.
Advice
- The acetylsalicylic acid in Aspirin is similar (but not identical) to salicylic acid used in acne treatments.
- Be patient when addressing skin issues. While improvements may not be immediate, your skin will gradually improve over time, even if it initially worsens. So, don't give up.
- Never pop pimples. This action only removes some bacteria, while the remaining bacteria stay beneath the skin and spread to other pores, resulting in more pimples.
- If your skin becomes irritated, reduce the number of times you apply Aspirin or stop using it altogether. Consult a doctor if irritation persists.
- Exfoliating is a great way to kill bacteria in pimples, so you should give it a try once.
- Wash your hands thoroughly before and after treating pimples on your face. Bacteria can make the pimples worse and lead to even more appearing on your face.
- Aspirin tablets without coatings are easier to crush.
- To dry out a pimple, you can apply a small amount of toothpaste and leave it overnight if you don't have Aspirin. Gel capsules of Aspirin are similarly effective.
- Clean your face before applying Aspirin.
Warnings
- Individuals with Reye's syndrome, those who have consumed large amounts of alcohol, are pregnant or breastfeeding, or are taking other medications should avoid this method.
- Avoid all aspirin products for individuals under 18 years of age or those showing symptoms similar to cold or flu.
- Aspirin has been associated with tinnitus. If you already have tinnitus, it is advised not to take aspirin.
- Do not use aspirin with other pain relievers. Only 100% aspirin should be used. This method does not work when combined with acetaminophen (Tylenol), ibuprofen (Advil), or other painkillers. Avoid using combination painkillers like Excedrin.
- Though rare, some people are allergic to aspirin. Test for allergy by applying a small amount of aspirin to the back of your ear.
- Do not use aspirin as a face mask, or if you do, limit it to no more than 3 tablets, applying for no more than 15 minutes and only occasionally.
- Since the body may absorb chemicals through the skin and the long-term effects of topical aspirin use are not well understood, using aspirin for acne treatment regularly is not recommended.