1. Giovanni Aldini
Giovanni Aldini aimed to resurrect the dead by using science to achieve his extraordinary goal. His invention, which seemed both absurd and supernatural, was his vision of a breakthrough that would earn humanity’s admiration. In 1803, Aldini began his experiments by working on the body of George Foster, a convicted murderer who had been executed. Aldini believed that by using a Volta battery to generate electrical currents, he could successfully revive the dead. Death, long considered a mysterious void in human imagination, led many scientists, including Aldini, to try and uncover its true nature. When Aldini applied the electrical currents to Foster’s body, the facial muscles contracted and his jaw trembled, with his eyes even opening. Spectators were stunned, thinking the experiment had succeeded, though the body did not come back to life—rather, the electrical stimulation had merely triggered reflex reactions in the muscles.


2. Shiro Ishii
When it comes to the most outrageous inventions in history, Shiro Ishii's name cannot be left out. A microbiologist by training, Ishii is most notorious for his role as the director of Unit 731, the infamous biological warfare division of the Imperial Japanese Army. His experiments, carried out with extreme cruelty, have left a dark legacy in the history of scientific misconduct.
In 1930, Ishii established a secret research facility where over 1,000 prisoners were held for his deadly biological experiments. These individuals were subjected to horrific and inhumane procedures, often without any hope of survival. At the facility, Ishii performed cruel experiments such as forced pregnancies, frostbite testing under anesthesia, and live surgeries without anesthesia. All of his experiments pushed the limits of human endurance, and the prisoners paid with their lives. Ishii personally oversaw or carried out these experiments to unlock the maximum potential of human physiology. Despite the massive loss of life and suffering he caused, Ishii was granted immunity from prosecution for war crimes in 1946 by the Japanese government before the Tokyo Tribunal.


3. Sidney Gottlieb
Scientists are often brilliant individuals with exceptional talents, but some also possess eccentric traits that lead them to view the world in unconventional ways. These outliers sometimes produce inventions that are considered bizarre and outlandish by the public. Though their innovations may not always serve practical purposes, the extraordinary intellect behind them cannot be denied. Sidney Gottlieb, a scientist with one of the most unconventional and 'crazy' inventions, is one such figure.
Sidney Gottlieb was notorious for his strange obsession with deadly toxins and his attempts to apply his discoveries in real-world scenarios. A brilliant scientist, he dared to explore dangerous substances that most would shy away from. Among his most infamous inventions was the creation of poison pills for CIA spies, which allowed agents to commit suicide without suffering prolonged pain if their cover was blown. To prove the effectiveness of his invention, Gottlieb secretly tested the poison on humans and even convinced an entire town to unknowingly take the poison in an effort to validate his experiment.


4. Harry Harlow
Animal testing was a common practice in earlier scientific research, although not all experiments were successful. The use of animals in experiments raises significant ethical concerns, as they are living beings whose lives are at risk. While successful experiments can benefit humanity, failed ones lead to the loss of innocent lives. The line between useful research and cruelty can be incredibly thin. Psychologist Harry Harlow conducted a controversial experiment using Rhesus monkeys, a species native to Asia, in his quest to understand the effects of isolation and loneliness.
Harlow's experiment involved isolating infant monkeys from their mothers and peers, locking them in a specially designed cage. For these young monkeys, the cage became a symbol of despair. As Harlow observed, the monkeys' emotional well-being deteriorated significantly, and they did not develop in a healthy manner. The isolation caused deep sadness and stunted their normal growth. Harlow hoped that his findings could help treat children with developmental delays or depression, though the cruelty of his methods remains widely criticized.


5. Vladimir Demikhov
What would you think if the lives of dogs were sacrificed for an experiment that everyone deems absurd and pointless? Dogs are known for their loyalty and close bond with humans, often helping us in numerous ways. Their lives are considered precious, and using them as test subjects is often seen as cruel. Despite the many objections, Russian surgeon Vladimir Demikhov proceeded with his controversial research centered around the idea of "symbiosis."
Symbiosis refers to two distinct organisms living together on the same body, a concept commonly seen in plants but almost unthinkable in animals or humans. Demikhov took this idea to the extreme by conducting an experiment where he grafted the upper body of a puppy onto the neck of a fully grown German Shepherd. The experiment, widely regarded as insane, was met with no support, and its results were catastrophic. The two dogs could not survive the procedure, as their cells rejected the foreign tissue, leading to their eventual death. This gruesome attempt at symbiosis remains one of the most notorious failed experiments in history.


